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GLUCOSAMINE KCL
Glucosamine KCL is a nutritional supplement used to reduce pain and inflammation associated with osteoarthritis. Some of the main benefits of glucosamine KCL include improved mobility and flexibility, relief from joint pain and stiffness, and improved joint function. Glucosamine KCL has also been shown to help reduce joint damage by stimulating proteoglycan and collagen synthesis, increasing joint lubrication and cartilage vitality.
It is a modern and innovative endogenous substance. It presents a much higher therapeutic action with a lower dose of active ingredient. It stimulates the physiological synthesis of glycosaminoglycans and proteoglycans by chondrocytes and hyaluronic acid by synoviocytes.
Pharmacodynamic effects
Early in vitro studies have shown that glucosamine sulfate KCL has anabolic and anti-catabolic effects on cartilage metabolism. More recent studies have postulated that glucosamine sulfate KCL decreases IL-1 β-mediated effects by inhibiting the cascade of events leading to joint inflammation and cartilage damage. Animal models confirmed the potential of glucosamine sulfate at human equivalent doses close to therapeutic doses in delaying disease progression and alleviating symptoms.
Clinical efficacy and safety
The safety and efficacy of Glucosamine KCL has been confirmed in clinical trials for the treatment of osteoarthritis for up to three years. Glucosamine KCL has demonstrated good tolerability in both long-term and short-term treatment.
Special populations
Patients with renal or hepatic impairment: Studies in patients with hepatic impairment were not performed given the metabolic fate of glucosamine as an endogenous substance. Therefore, no dose adjustment is considered necessary in patients with renal or hepatic impairment.
Children and teenagers: The pharmacokinetics of glucosamine have not been studied in children and adolescents.
Elderly patients: No specific pharmacokinetic studies have been performed for elderly patients; however, clinical safety and efficacy studies included mainly elderly patients. No dose adjustment is required.
